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KMID : 0378019650080010093
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New Medical Journal
1965 Volume.8 No. 1 p.93 ~ p.98
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The Experimental Studies of the Influences of Cortisone and Vitamins on the Fracture Healing
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Abstract
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The Experimental Studies of the Influences of Cortisone and Vitamins on the Fracture Healing
Report 3. An Experimental Study of the Influences of Vitamin A and Cyanocobalamin on the Fracture Healing.
Dae Young Kim, D. D. S.
College of Dentistry, Seoul National University
The influences of Vitamin A and cyanocobalamin on the mucopolysaccharide and sulfuric acid which play the important roles in the fracture healing were studied in the rats. Thirty mature healthy rats were divided into 3 groups, 10 in each. The first group was the control animals to which 0.2 ㎖ of physiological saline was intramusculary given at the 3 days intervals for 21 days. The second group received 30㎎ of Vitamin A, and the third, 15 ㎍ of cyanocobalamin instead of the saline. S^(35) was subcutaneously given to each group 24 hours before the sacrifice in the same doses dated in the Report 1. The distribution of S^(35) and the histopathological changes were studied with the macro-, and microautoradiography in accordance with the special metachromic staffing with toluidine-blue and eosin.
Following were the results:
1. Vitamin A induced an increase of S^(35) uptake in the growing portions of the bones and fracture sites.
2. In the Vitamin A treated animals, a clear halous blackening with the metachromic appearance was present in the chondroid matrix which was surrounded by an irregular fibrous bundle.
3. In the cyanocobalamin treated animals, a large amount of chondroblasts appeared in the healing sites and the S^(35) uptake was also active, however, the osteoblasts were not observed.
4. Vitamin A and cyanocobalamin enhanced the differentiation of the chondrocytes in the fracture sites, epi- and diaphyses and also formed an excess sulfated mucopolysaccharide complex in the fracture sites.
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